From now on (25th), our city started to strengthen the immunization appointment registration of recombinant Covid-19 vaccine for inhalation (adenovirus type 5 vector). Strengthening immunization will be started tomorrow (26th). What is recombinant Covid-19 vaccine for inhalation? How effective, persistent and safe is this vaccine? What are the conditions and taboos for inoculating recombinant Covid-19 vaccine for inhalation? See ↓
Studies at home and abroad have proved that enhanced immunization with Covid-19 vaccine can enhance the protection effectiveness and prolong the protection period. Up to now, more than 23 million citizens in this city have completed the whole vaccination of COVID-19 vaccine, among which more than 12 million citizens have completed the intensive immunization. Citizens who have not yet been vaccinated need to complete the vaccination as soon as possible. According to the deployment of the joint prevention and control mechanism in the State Council, the city started to strengthen immunization with recombinant Covid-19 vaccine for inhalation (adenovirus type 5 vector) on October 26th, 2022.
For people aged 18 and above who have been vaccinated with inactivated vaccine produced by Sinopharm China Biotechnology Co., Ltd., Wuhan Biological Products Research Institute Co., Ltd. of Sinopharm China Biotechnology Co., Ltd., Beijing Kexing Zhongwei Biotechnology Co., Ltd. and intramuscular recombinant COVID-19 vaccine (adenovirus type 5) produced by Kangxinuo Bio-stock Company for 6 months, they can choose to use recombinant Covid-19 vaccine for inhalation (adenovirus type 5) to carry out one dose of booster immunization. This intensive immunization is free of charge.
According to the relevant requirements of the state, citizens only need one dose of hypohomologous booster immunization or sequential booster immunization at present.
From October 25, 2022, eligible citizens can make online APPointment registration for enhanced immunization through the "Healthy Cloud" app. Bring your valid ID card to the scheduled vaccination clinic at the appointed time for intensive immunization. When people aged 70 and over are vaccinated, they should be accompanied by family members or volunteers.
Foreigners in Shanghai, compatriots from Hong Kong, Macao and Taiwan should be immunized with recombinant Covid-19 vaccine (adenovirus type 5) by inhalation, and it is still carried out in accordance with the relevant policies and requirements of previous immunization.
Q1. What is recombinant Covid-19 vaccine for inhalation?
A: The recombinant Covid-19 vaccine for inhalation (adenovirus vector type 5) uses the adenovirus vector which is harmless to human body to deliver the genetic material expressing S protein into human body, and uses an atomizer to atomize the vaccine into tiny particles, which reach the lung tissue through oral breathing by inhalation, thus stimulating triple immunity of mucosa, body fluid and cells.
Q2. What are the conditions for inoculation of recombinant Covid-19 vaccine for inhalation?
A: At this stage, the inactivated vaccine produced by Sinopharm China Biotechnology Co., Ltd., Beijing Institute of Biological Products Co., Ltd., Sinopharm China Biotechnology Co., Ltd., Wuhan Institute of Biological Products Co., Ltd. and Beijing Kexing Zhongwei Biotechnology Co., Ltd. and the intramuscular recombinant COVID-19 vaccine (adenovirus type 5) produced by Kangxinuo Biological Co., Ltd. can be used to carry out one dose of booster immunization for people aged 18 and above for six months. Recombinant Covid-19 vaccine for inhalation (adenovirus type 5 vector) is not used for basic immunization for the time being.
All kinds of people only need to be vaccinated with one dose of hypohomologous booster immunization or sequential booster immunization.
Q3. What is the dose of recombinant Covid-19 vaccine for inhalation?
A: the dosage is 0.1mL each time.
Q4. Can people over 60 be vaccinated? Can people under 18 be vaccinated with recombinant Covid-19 vaccine for inhalation?
A: The recommended vaccination population for inhalation dosage form is people aged 18 and above.
Q5. How effective is the booster immunization with recombinant Covid-19 vaccine for inhalation?
A: At present, the clinical study of sequential booster immunization with recombinant Covid-19 vaccine for inhalation and inactivated novel coronavirus vaccine in healthy adults aged 18 and above in China shows that sequential booster immunization with recombinant Covid-19 vaccine for inhalation and inactivated vaccine can significantly enhance the immune response.
Q6. What is the immune persistence of recombinant Covid-19 vaccine for inhalation?
A: The study of immune persistence showed that after 6 months of heterologous inoculation with recombinant Covid-19 vaccine for inhalation, the neutralizing antibody remained at a high level.
Q7. What is the safety of recombinant Covid-19 vaccine for inhalation?
A: The results of a safety study among tens of thousands of people showed that the recombinant Covid-19 vaccine for inhalation was safe in people over 18 years old, and no serious adverse reactions were found.
Q8. What are the contraindications of recombinant Covid-19 vaccine for inhalation?
A: (1) Those who are allergic to the active ingredients, any inactive ingredients and substances used in the production process of this product, or those who have been allergic to similar vaccines before.
(2) Those who have had severe allergic reactions to vaccines in the past (such as acute allergic reactions, angioneurotic edema, dyspnea, etc.).
(3) Patients with uncontrolled epilepsy and other progressive nervous system diseases have a history of Guillain-Barre syndrome.
(4) People who are suffering from fever, acute diseases, acute attacks of chronic diseases, or uncontrolled patients with severe chronic diseases;
(5) Pregnant women.
Q9. Can patients with chronic diseases be vaccinated with recombinant Covid-19 vaccine for inhalation?
A: According to Technical Guidelines for Vaccination in Covid-19 (First Edition), people with chronic diseases are at high risk of severe illness and death after being infected with Covid-19. People with chronic diseases with stable health and good drug control are recommended to be vaccinated. Vaccination is suspended when chronic diseases are in acute attack. Have a history of convulsion, epilepsy, encephalopathy or mental illness or family history; Have a history of asthma, chronic obstructive pulmonary disease, pulmonary fibrosis and other basic diseases or abnormal lung function; Use with caution in patients with impaired immune function (such as malignant tumor, nephrotic syndrome and other immunodeficiency diseases).
Q10. Do people cured in COVID-19 need to be vaccinated with recombinant Covid-19 vaccine for inhalation?
A: According to the Technical Guidelines for Vaccination in Covid-19 (First Edition), it is rare for Covid-19 to be reinfected within 6 months after infection. In the past, COVID-19 virus infected people (patients or asymptomatic infected people) can be vaccinated with one dose after 6 months on the basis of full notification.
Q11. Can people with allergies be vaccinated with recombinant Covid-19 vaccine for inhalation?
A: According to the Technical Guide for Vaccination in Covid-19 (First Edition), those who have had severe allergic reactions to vaccines in the past (such as acute allergic reactions, angioneurotic edema, dyspnea, etc.) are contraindications for vaccination of Covid-19 vaccines; In addition, the severity of allergies and allergens should be considered and implemented according to the doctor’s advice.
Q12. How to inoculate recombinant Covid-19 vaccine for inhalation?
A: Please practice several times before inhaling, and then start the formal inoculation.
Step 1: Take a deep breath first (do not exhale into the atomizing cup);
Step 2: hold the nozzle of the atomizing cup in your mouth, and inhale deeply until there is no fog in the cup;
Step 3: Hold your breath for more than 5 seconds (at least 5 seconds), then breathe normally, and the inoculation is over.
Q13. Under what circumstances should I inhale the recombinant Covid-19 vaccine for inhalation again on the spot?
A: (1) There is obvious misty gas in the atomizing cup after inhalation;
(2) Cough and early exhalation occur during inhalation (including 5-second breath-holding period).
Suction failure needs to inhale a dose of vaccine again, and only one repeated inhalation is allowed.
Q14. What should I pay attention to after vaccination with recombinant Covid-19 vaccine for inhalation?
A: After inoculation, you should stay on the spot for at least 30 minutes; Avoid contact with previously known allergens and common allergens within one week after inoculation, and try not to drink alcohol, eat spicy food or seafood. It is recommended to have a light diet and drink plenty of water.
Q15. What adverse reactions may occur after vaccination with recombinant Covid-19 vaccine for inhalation?
A: Common systemic adverse reactions include fatigue, headache, fever, dry mouth and swollen throat. Generally, they can recover by themselves without special treatment.
Q16. Will the inoculation of recombinant Covid-19 vaccine for inhalation affect the results of nucleic acid test and antigen test?
A: The characteristic of adenovirus vector COVID-19 vaccine is that it only contains the gene sequence of S protein and expresses antigen in human cells, and it does not contain nucleic acid detection site open reading frame 1ab(ORF1ab) and nucleocapsid protein (N protein). Therefore, the vaccination of this vaccine will not lead to the positive detection of COVID-19 nucleic acid.
COVID-19 vaccination point for inhalation
(October 24, 2022)
Note: Subsequent districts will make dynamic adjustments according to the actual situation.
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