标签归档 上海狼盟

The most cost-effective Chery Jaguar Land Rover New Energy Precipitation is a classic.

Nowadays, when consumers buy a car, safety configuration is one of the most important considerations, so whether active/passive safety configuration is rich or not will directly affect its popularity. There are many choices of cars now, as we said today. Let’s take you to appreciate its style.

Let’s take a look at the appearance of plug-in hybrid in evoque. The style of plug-in hybrid front in evoque looks very stylish and simple, and looks very simple. At the same time, the headlights present a spiritual design style, and the shape is quite young and individual. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car body, the size of the car body is 4531 mm * 1904 mm * 1650 mm. The car adopts exquisite lines, and the car body looks very simple. With large-sized thick-walled tires, the shape is quite round. In terms of the rear end, the rear end looks very hard, the taillights look very simple and generous, and the overall layout is impressive.

Sitting in the car, the interior modeling has taken a full route, and the overall design of the gas field is still in place. The steering wheel of the car is well designed, made of genuine leather, and the visual effect is good. Let’s take a look at the central control, with an 11.4-inch central control screen, which makes the interior style impressive and looks simple. The interior feels good. Let’s take a look at the dashboard and seats. The dashboard design is remarkable, and the information is easy to read and clear. The car adopts leather-like seats, which are wide and thick, improving the riding experience of drivers and passengers.

The space performance of plug-in hybrid trunk in evoque is OK. If there are big items during the trip, the rear seat can be put down, which is not a problem for daily use. At the same time, the car is equipped with fatigue warning, anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), brake force distribution (EBD) main driver airbag, co-pilot airbag, side airbag curtain, front side airbag and other safety configurations.

OK! Next, let’s sum up. The SUV has an atmospheric appearance, good spatial performance and high cost performance. I wonder if you are interested in it.

The list of endangered Yangtze finless porpoises for 20 years has not further affected the protection effect

  Original title: The Yangtze finless porpoise is on the verge of "extreme danger"-the national key protection list has not been updated for 20 years, which leads to the lag of law enforcement and affects the protection effect

  The existing list of species protection in China has not been systematically updated in the past 20 years. The list of national key protected wild animals was promulgated in 1989, and the list of national key protected wild plants (the first batch) was promulgated in 1999, and it has only been fine-tuned once so far; The List of National Key Protected Wild Plants (Second Batch) has been in the state of "discussion draft" and has not yet been officially promulgated.

  The past two or three decades have witnessed the fastest economic development and urbanization in China, especially in the eastern and southern parts with high population density. Many natural habitats have been developed and changed, and resource utilization and human activities have intensified, resulting in habitat loss and fragmentation, which has greatly reduced the distribution and number of wild animal populations.

  The population of the Yangtze finless porpoise, which was once affectionately called "Jiang Pig" by the residents along the Yangtze River because of its naive and extremely common behavior, has declined rapidly in the past 20 years, from 2,700 in 1991, 1,800 in 2006 and 1,050 in 2012 to less than 1,000 now-a figure that worries people who care about the protection of the finless porpoise.

  Following the functionally extinct baiji, the Yangtze finless porpoise has been known as the "giant panda in the water" for more than 10 years, and the recent related research has even divided the Yangtze finless porpoise into an independent species. However, the "giant panda in the water" has not been treated as a giant panda: in the list of key protected wild animals in China, the finless porpoise has not changed since it was designated as a second-class protected animal in 1989. Although experts and conservation organizations keep calling for upgrading, the Ministry of Agriculture and the State Council have issued documents to strengthen the protection of finless porpoises, but the adjustment of the list involves the coordination and unification of various departments in charge of wildlife protection, so it has not been realized.

  The lag of protection level cannot be said to have no influence on the living conditions of Yangtze finless porpoises today.

  In January 2018, the only South China Golden Cat in the global zoo died in Hangzhou Zoo. Li Jian photo/bright picture

  The Red List of Endangered Species published by IUCN divides the endangered species into nine grades, which are evaluated and updated by experts all over the world about every five years. It also includes the evaluation results of China species regularly organized by the National Endangered Species Science Committee of China, that is, the Red List of China Species. The rating of Yangtze finless porpoise in IUCN Red List was "endangered" in 2000, and it was upgraded to "extremely endangered" in 2013, only one step away from "extinction in the wild".

  China Nature Watch 2016, an independent analysis report jointly issued by a number of nature conservation agencies and the Research Center for Nature Conservation and Social Development of Peking University, pointed out that the IUCN Red List involves threatened species in China (including critically endangered, endangered and vulnerable), and 405 of them are not included in China’s protection list; However, 197 species in China’s protected list are "non-endangered" species in IUCN’s red list-this means: on the one hand, a considerable number of endangered species are not protected by Chinese laws; On the other hand, some species that are not endangered may occupy limited conservation resources.

  Specifically, there are the following situations:

  First, it has been endangered for a long time but has never been included in the list. For example, the spoonbill snipe is a migratory bird passing through the eastern and southern coastal beaches of China. At present, the population in the world is estimated to be less than 100 pairs, and the habitat along its migration route, especially the development of coastal wetlands in East Asia, is the main reason for the extreme endangerment of this species. The IUCN Red List assessed it as endangered in 2004, and soon adjusted it to extremely endangered in 2008. However, this species was not included in the list of key protected animals in China, but only appeared in the List of Terrestrial Wild Animals Protected by the State (referred to as the "Three Lists").

  Second, in the past 20 years, it has become endangered from no danger. For example, the well-known "sparrowfinch", the yellow-breasted flounder, still had a huge population and was widely distributed in the 1990s. In 2000, it was assessed as a non-endangered species in the IUCN Red List, and then its population plummeted due to excessive killing and eating and the large occupation of rice fields in its main habitat, and it was assessed as extremely endangered in 2017. At present, the sparrows are not listed in the List of National Key Protected Wild Animals.

  Third, it has been included in the protection list, but the level is lower than the actual endangered situation. In addition to the Yangtze finless porpoise, another example is the yellow-lipped fish, a species endemic to China, which is rated as extremely dangerous in the IUCN Red List. But like finless porpoises, yellow-lipped fish is only Grade II in the List of National Key Protected Wild Animals. Yellow-lipped fish is one of the rarest species in the family Sciaenidae, with low protection rating, serious lack of public concern and national protection; In addition, some news media reported positively that fishermen caught yellow-lipped fish and sold it at a sky-high price, which aggravated the pressure of overfishing on this species.

  Fourth, the list of the second batch of key protected plants has been delayed, and a number of endangered plants cannot be effectively protected. More than 2,000 species of plants threatened with extinction in the "second discussion draft" have not been protected by law due to disputes over jurisdiction by several competent authorities. Most of these plants have great economic value, so the wild population is over-utilized. For example, there are no restrictions on the mining and trading of wild ginseng in China, and sometimes it is even encouraged by individual news media. The situation is similar to that of wild Dendrobium candidum and Dendrobium huoshanense.

  Fifth, some species endemic to China, but not endangered, are listed in the protection list. For example, Davidia involucrata, clover and Tibetan wild donkey are all national first-class protected species, but the number of wild populations is very large. According to China Nature Watch 2016, the protection of these species is improving.

  China Nature Watch 2016 also assessed the protection status of all species in the current List of National Key Protected Wild Animals/Plants and all China species (1085 in total) on the threatened list in the IUCN Red List from 2000 to 2015. The results show that only 102 species have improved, 738 species have deteriorated, and the remaining 245 species lack information.

  It can be seen that the outdated list leads to the lag of law enforcement, which is one of the reasons for the deterioration of the protection of quite a few threatened species. There are many reasons why the catalogue has not been updated, and the lack of species information, especially the reliable information of population number, actual distribution and change, is only one of them. With the country’s attention to species protection and the promotion of the whole society’s awareness of protection, especially the opportunities for the general public to participate in natural observation of birds and beasts are increasing and deepening, and the information gaps are being filled step by step. Another major obstacle affecting the updating of the directory is the deadlock caused by the difficulty in coordinating multi-sector management. It is expected that the integration of natural resource management departments will help solve the problem of multi-sector management of wildlife protection. In fact, the People’s Republic of China (PRC) Wildlife Protection Law (Revised Draft), which came into effect on January 1, 2017, has written into the law that the list of protected animals should be updated every five years. Therefore, it is imperative to update the list as soon as possible.

  For the adjustment of the list, we suggest to establish an evaluation standard based on experts and scientific data on the basis of referring to the research reports such as IUCN Red List of Endangered Species, China Red List of Species and China Nature Watch 2016, and comprehensively sort out and rate the species in China, so as to adjust the protection level. For example, the IUCN Red List can include endangered and extremely endangered species, and the species with a score lower than -2 (inclusive) in the reference of China Nature Watch 2016 can be adjusted as national first-class key protected species; Adjust (or reserve) flagship species such as giant panda, snow leopard and Chinese white dolphin, umbrella species and top predator species in the ecosystem as national first-class key protected species; The species in the discussion draft of "List of National Key Protected Wild Plants (Second Batch)" will be officially promulgated to make it legally effective. In principle, non-endangered and low-endangered species will not be removed from the list, but only downgraded. For example, if the species in the current protection list are non-endangered and near-endangered in the IUCN Red List, and the score in China Nature Watch 2016 is higher than -1 (inclusive), it will be adjusted to the national second-class key protected species; Extinct species are indicated separately; Remove the taxonomically proved species (such as heterophylla japonica) from the list.

  We earnestly hope that the "Updated List of National Key Protected Species" will be put on the legislative agenda as soon as possible and promulgated as soon as possible, so that all the truly endangered species can be protected by law.

  Source: Guangming Daily

New plug-in hybrid version Dongfeng Honda’s new CR-V is expected to be launched in July.

Yichexun  Recently, it was learned from relevant channels that the new CR-V is expected to be listed around July this year. Judging from the previous declaration, the overall style is younger and consistent with the overseas version. It is worth mentioning that a plug-in version will be added to the new car, which is also the first plug-in hybrid model launched in China.

Details such as the mesh grille have been adjusted.

In terms of appearance, there is little difference between the new CR-V and the current one. The main changes in styling are concentrated in the front face, but the size of the air intake grille of the new car is further increased, and the lower enclosure is chrome-plated. The front face looks more stereoscopic and more recognizable.

Compared with cash, the new model has changed in details.

The change of the tail is also reflected in the details. The new rear has added silver, which echoes the front face. The fuel version adopts the layout of bilateral double exhaust, and the hybrid version has added a tail label to highlight the hybrid identity. The Black Edition black kit is expected to be added to the top model. The front enclosure is outlined by black decoration and chrome strips, and the rear enclosure is changed to pure bright black paint. At the same time, it is equipped with a black outer shell and 19-inch bright black wheels, which looks more sporty.

The new model will add a plug-in hybrid version.

In terms of power, according to the declaration information of previous exposure, the new car version will be equipped with 1.5T, and the power parameters are the same as those of the current model. The hybrid version will be equipped with 2.0L motor, of which 107kW, 175N.m, and the driving motor is 135kW, 315N.m We have not got the parameters of the plug-in hybrid version yet, and more news will continue to be paid attention to.

Temporary closure of the community where the newly confirmed cases are located in Beijing! How to protect the needs of pregnant women and seriously ill patients?

  On January 15th, a new case of COVID-19 was confirmed in Beijing. The case lives in Boya Xiyuan, South Agricultural University Road, shangdi street, Haidian District, and its recent whereabouts involve many shopping centers in Haidian, Chaoyang and Changping, Beijing.

  Zhao Chengfang, deputy director of the Haidian District Health and Health Commission, said that at present, all risk points in Haidian District, including the trajectory of cases, involve about 13,000 people in total nucleic acid testing. The nucleic acid detection of all risk points involved in the case action trajectory has been completed, and the results are negative. At present, how is the flow adjustment work progressing? What service guarantee work has been carried out in the community with temporary closure measures?

The community where the case is located has implemented temporary closed management.

  Yesterday (16th), the reporter saw in Boya Xiyuan Community, shangdi street, Haidian District, Beijing that all entrances and exits of the community had been closed, and the staff wearing protective clothing were killing the public areas in the community.

  Yu Xiuhong, deputy director of the shangdi street office, said that under the guidance of the municipal and district disease control departments, the community has completed the precise prevention and control of closed control areas, control areas and prevention areas. There are 20 buildings in the whole community, only building 7 where the case is located is a closed control area, and the rest of the community is a control area.

  △ Boya Xiyuan Community adopts control and sealing measures.

  Yu Xiuhong said,They determined the scope of sealing control with the advancement of flow regulation, and did not do sealing control in the whole community at once. "If there is a problem with a certain doorway, you should only do the work for this doorway, and it will not cause a one-size-fits-all phenomenon. In the closed building, every household can’t go out, and other residents can move in the public area of the community without gathering. In addition, the time for home observation is also different. "

Hundreds of people joined the community service guarantee team.

Escort pregnant women and seriously ill patients.

  Shangdi street organized the sinking of all 158 on-the-job cadres, and at the same time, more than 200 volunteers and social workers joined the community service guarantee team.

  Yu Xiuhong introduced that the temporary closure of the community entered the second day, and all kinds of "fine work" such as buying food and medicine were an examination of the fine management ability of the community. "This is a very detailed and trivial work. For example, there are three Boya (Xiyuan) communities now.Maternal We have to report in advance according to the hospital where she wants to have a check-up, and contact 120 ambulances one day in advance to send her to complete the closed-loop check-up in time. For example, needdialysis We need to know the patient’s condition, the fixed time of dialysis, the physical indicators related to epidemic prevention and control, and whether he meets the standard of leaving the community. On this basis, we need to dock with his designated hospital. "

  △ Boya Community Neighborhood Committee staff records residents’ needs

  There are 2,928 permanent residents in Boya Xiyuan Community. At present, the nucleic acid detection of all people has been completed, and all the others are negative except the confirmed cases. Checking all kinds of information and meeting the diverse needs of residents became the focus of community workers yesterday (16th). The reporter saw at the Boya Xiyuan Community Epidemic Prevention and Control Command.Information on residents’ special needs, including maternity check-ups, cancer follow-up visits, renal dialysis, etc., has been collected in a table, and there is one-on-one service by special personnel. .

  Tan Jing, secretary of the Party branch of Boya Xiyuan Community and director of the neighborhood committee, said: "The residents’ psychological state was not very stable in the early stage, so we also took this into account in the later stage and carried out one-on-one assistance and guidance. We also provided one-on-one assistance to empty nesters and elderly people living alone in the community. "

  It is understood that every residential building in the community now collects residents’ demand information through the WeChat group, and residents send demand orders in the group. Residents who need to buy daily necessities can also directly scan the QR code to place orders, and the supermarket will complete the distribution. For online shopping of living materials and other express delivery, the property staff will strictly kill them, deliver them to the door according to the control requirements, and complete non-contact distribution. Some older residents can’t buy online, so volunteers take on the task of running errands part-time.

After environmental disinfection and nucleic acid detection

Some shopping malls involved in the track of the case.Business has resumed.

  It is understood that the trajectory of this confirmed case involves many shopping centers, and some shopping places have resumed normal business after completing environmental disinfection and nucleic acid testing for all staff.

  The reporter from Voice of China, the general station, visited and learned that only Qinghe Wanxianghui, which was visited on January 2, among the shopping centers involved in the case’s whereabouts, is still temporarily closed, and professional institutions are completing deep disinfection, and the resumption time is not yet clear.

  The Financial Street Shopping Center issued a statement saying that the mall was closed for one day yesterday (16th), and it has been completely sterilized and cleaned. The results of nucleic acid tests in the store environment, brand shop assistants and staff were all negative, and it will resume normal business today.

  The reporter noted that,In addition to the above two shopping centers that have temporarily closed their stores, the commercial centers involved in the travel trajectories of other cases will close their stores as much as possible, or maintain normal business under the premise of ensuring safety.

  For example, Wynn International, at present, only the theater on the first floor of the basement where the case watched the performance on January 2 is temporarily closed, and other stores are open normally. In addition, AEON Shopping Mall in Changping and SKP in Beijing in Chaoyang are currently operating normally. The announcement issued by SKP yesterday (16th) showed that the case wore a mask all the time during the store, and all the service staff who received it wore masks all the time.

  △ Statement issued by Beijing SKP

  The reporter further verified that a certain brand store visited by the confirmed case was not closed. SKP store staff:

  "No, just come directly."

  "It doesn’t matter, we all made nucleic acids. I can only go to work with the results. "

The tracing of flow regulation is still in progress.

  According to the staff of Beijing CDC, on January 15th, the travel track of the confirmed cases within 14 days has been investigated clearly, and the risk points have been cleared.At present, the CDC is still trying to find a way to investigate the source. In view of several major shopping malls and buses where the case has been active, further sampling and screening were quickly carried out, hoping to find clues. So far, no other positive cases have been found.

  The "Guidelines for the Determination and Management of Close Contacts of COVID-19 Epidemic" (the eighth edition) makes it clear that the determination of close contacts begins two days before the symptoms of suspected cases or confirmed cases appear, or two days before the sampling of asymptomatic infected persons, and people who have close contact with them but have not taken effective protection. There are several specific principles for judging migrant workers, such as family members living together in the same room, people sharing meals and entertainment in a closed environment, and people providing catering and entertainment services.

  At present, the flow control personnel are stepping up efforts to further refine the source of the flow control, seize the time to investigate the secret and sub-secret personnel and implement centralized isolation, strictly implement epidemic prevention and control measures for relevant personnel and regions, and resolutely block the transmission channels of the virus. For details, the Voice of China, the general station of Yangguang, will continue to follow up.

Source of this article: Voice of China (ID: zgzs001), Central Radio and Television General Station

  Reporter Yang Guang from the General Desk/Li Xingjian

Interpretation of the brand-new guidelines for diagnosis, treatment and management of asthma, everything you want to see is here.

Interpretation of Global Asthma Management and Prevention Strategy Update in 2022 Edition

Correspondent: Sun Yongchang, professor, chief physician.

SETTING: Department of Respiratory and Critical Care Medicine

A cross-sectional study of the first phase of the global asthma network published by The Lancet shows that by providing effective asthma treatment, the heavy burden of severe asthma symptoms in the world can be reduced. However, the prevalence of asthma in China is increasing year by year, and the overall control level of asthma in China is still not ideal. On World Asthma Day in 2022, global initiative for asthma Expert Group released the 2022 edition of Global Asthma Management and Prevention Strategy (GINA 2022). As an important guide for global asthma prevention and control, what are the important revisions of GINA 2022?

Based on this, this paper interprets the update points of GINA 2022, discusses the management of asthma during COVID-19 epidemic, and puts forward the reference significance for the diagnosis and treatment of asthma in China.

01、The diagnostic procedure of asthma was revised.

1.GINA 2022 pointed out that the examination method needed for diagnosis depends on whether the patient has received controlled treatment or not, and explained the matters needing attention during examination, as shown in Figure 1.

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2、For patients who have not received controlled treatment, evidence helpful for asthma diagnosis should be recorded when asthma symptoms appear for the first time; For patients who have received controlled treatment, if the diagnosis basis of asthma has not been recorded before, they should be diagnosed through objective tests, as shown in Table 1.

How to reduce the control treatment to help confirm the diagnosis process of asthma is shown in Table 2.

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02、Diagnosis and treatment of asthma in low-and middle-income countriesThe treatment plan provides suggestions.

1.GINA 2022 provides detailed guidance on the diagnosis and management of asthma in resource-poor areas. Among them, differential diagnosis usually needs to include endemic respiratory diseases and infections, tuberculosis and human immunodeficiency virus (HIV)/ AIDS.

2.GINA 2022 does not recommend diagnosis only based on clinical symptoms. When the pulmonary function cannot be measured, the peak expiratory flow (PEF) can be used to confirm that the variable expiratory flow is limited.

3.The World Health Organization (WHO) basic non-communicable diseases (PEN) intervention package lists PEF detection as a basic tool for managing chronic respiratory diseases, and WHO-PEN suggests that compared with COPD and other diagnoses, the improvement of PEF by ≥20% after inhaling 2 sprays of salbutamol for 15 minutes can increase the possibility of asthma diagnosis.

4.GINA 2022 also suggested that after 4 weeks of anti-inflammatory experimental treatment and 1 week of oral glucocorticoid (OCS) treatment if necessary, if the symptoms and PEF are improved, it will help to diagnose asthma (or prompt other diagnosis) before starting long-term controlled treatment.

03、On-demand inhaled glucocorticoids (ICS)- formoterolThe role of frequency of use in asthma control evaluation

ICS- formoterol as a remission agent, its frequency of use (≤2 times/week or > 2 times/week) is not included in the comprehensive evaluation of symptom control. However, the average frequency of using ICS- formoterol on demand should still be considered in the treatment decision.

04、Opinions on the severity of disease and "mild asthma"

GINA 2022 suggested that the word "mild asthma" should be avoided as much as possible in clinical practice; If it is used, the risk of serious attack and the necessity of using ICS-containing treatment scheme should be reminded.

05、Treatment of asthma

In the maintenance treatment of asthma, some issues are still controversial, such as the use of long-acting anticholinergic drugs (LAMA), whether to add some new biological targeted drugs to the fifth grade treatment of asthma, etc. GINA 2022 recommended the above problems and provided evidence. See figure 2.

62391662685468841  

Specific to the treatment of asthma in adults and adolescents, GINA 2022 emphasizes the reasons for two treatment paths:

Path 1, ICS- formoterol is used as a remission agent as needed in the treatment process because it has lower risk of acute attack and similar symptom control effect compared with SABA as a remission agent.

Path 2, GINA 2022 also added other evidence for the low-dose on-demand use of ICS- formoterol in step 1-2, including systematic review showing that the on-demand use of ICS- formoterol significantly reduced the risk of emergency treatment or hospitalization compared with daily ICS combined with on-demand SABA. GINA 2022 included anti-TSLP as a new biotherapy for severe asthma in step 5, and introduced it in detail in the guide to severe asthma.

06、Decision Tree of Refractory and Severe Asthma in Adults and Adolescents

(1)GINA 2022 clearly points out that for patients with refractory asthma whose blood eosinophils are ≥300 /μl, before considering biotherapy, we should evaluate whether there are any non-asthmatic causes, including strongyloides infection (strongyloides infection is usually asymptomatic). For patients with eosinophilia (blood eosinophils ≥1 500 /μl), eosinophilic granuloma with polyangiitis (EGPA) and other reasons should be considered, and the use of anti-IL4R should be avoided, because such patients were not included in the phase III study.

(2)GINA 2022 decision tree mentioned that tezepelumab is an additional biotherapy for severe asthma patients over 12 years old, and it has the greatest benefit in reducing the risk of acute exacerbation for patients with hypereosinophilia or screaming out nitric oxide (FeNO).

(3)Anti-IL4R is added for adults and teenagers.

(4)Anti-IgE is added during pregnancy, and there is very little evidence about the treatment of severe asthma during pregnancy, and the risk of using biotherapy during pregnancy needs to be weighed against the risk of uncontrolled asthma to mother and baby. A registered study found that using omalizumab during pregnancy did not increase the risk of congenital malformation.

(5)GINA 2022 added the results of systematic review and meta-analysis of patients with eosinophilia and type 2 asthma with additional application of anti-IgE, anti-IL5/5R and anti-IL4R.

(6)Maintenance OCS is only used as the last treatment for all age groups when other treatments are ineffective and there is no alternative.

(Note: You can swipe up and down to see more)

07、Asthma-chronic obstructive pulmonary disease (ACO)

(1) Definition: ACO and asthma+chronic obstructive pulmonary disease (COPD) are used to collectively refer to patients with persistent airflow limitation with clinical characteristics of both asthma and COPD. This is not a definition of a single disease, but is used to describe some clinical phenotypes with different pathogenesis.

(2) Diagnosis: See Table 3 for the most helpful clinical features and corresponding recommended treatments to distinguish asthma from COPD, and Table 4 for the pulmonary function features of ACO.

(3) Treatment: initial treatment (see Table 3), ACO should be treated as asthma, and ICS is the key to treatment.

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Referral examination, it is recommended to refer for further diagnosis and evaluation in the following cases:

① Patients with persistent and/or worsening symptoms after treatment;

② The diagnosis is uncertain, especially the need for further differential diagnosis, such as bronchiectasis, post-tuberculosis scar, bronchiolitis, pulmonary fibrosis, pulmonary hypertension, cardiovascular diseases and other diseases that cause respiratory symptoms;

③ Suspected asthma or COPD with atypical symptoms or other symptoms and signs (such as hemoptysis, obvious emaciation, night sweats, fever, bronchiectasis or other structural lung diseases) should be referred as soon as possible without waiting for the treatment trial of asthma or COPD;

④ When chronic airway diseases are suspected, but the characteristics of ACO are few;

⑤ Complications of patients may affect the assessment and management of respiratory diseases;

⑥ According to GINA and GOLD, problems during the treatment and management of asthma, COPD or ACO should also be referred.

08、Other update points

(1) Using electronic cigarettes will increase the risk of respiratory symptoms and acute exacerbation of asthma;

(2) Air filter can reduce the exposure of fine particles, but there is no consistent result for the prognosis of asthma;

(3) Updated the evidence of correlation between air pollution and the utilization of emergency medical care resources for asthma;

(4) Electronic inhaler detection can identify the compliance of patients with refractory asthma;

(5) In the patients who have used the treatment scheme containing moderate-high dose ICS, but the asthma symptoms are still not controlled, high blood eosinophil level and high FeNO level are related to the high risk of acute exacerbation of asthma;

(6) Patients hospitalized due to acute asthma attack should continue or be given a treatment plan containing ICS.

Management of asthma during COVID-19 epidemic

1. Management of asthma during 1.COVID-19 epidemic.

GINA 2022 pointed out that asthma patients did not seem to have an increased risk of COVID-19 infection. However, it should be noted that the risk of death caused by COVID-19 increases in patients who need OCS for asthma and hospitalized patients with severe asthma. It shows that it is very important to continue good asthma management, and active measures should be taken to maintain good symptom control, reduce the risk of acute exacerbation of asthma and minimize the demand for OCS.

2. The requirements of epidemic prevention and control should be considered in the process of asthma management.

If it is impossible to test lung function due to the restriction of local epidemic prevention and control, and the information about lung function is needed, we can consider asking patients to test lung function at home. Some treatment measures, such as oxygen therapy, sputum induction, manual ventilation, non-invasive ventilation and intubation, can lead to the generation of aerosol, so we should follow the local health strategies and health suggestions on the use of personal protective equipment in accordance with the requirements of epidemic prevention and control.

3. Suggestions on vaccination of asthma patients with COVID-19 vaccine.

(1)GINA suggested that patients with asthma should be vaccinated with COVID-19 vaccine in time and booster if possible. At the time of vaccination, the usual vaccine preventive measures are also applicable to asthma patients.

(2) For patients undergoing biotherapy, the first dose of biotherapy and COVID-19 vaccine should not be injected on the same day, so as to identify their adverse reactions more easily.

(3)GINA also reminded that asthma patients should be vaccinated with influenza vaccine every year, and influenza vaccine and COVID-19 vaccine can be vaccinated on the same day. In addition, even if vaccinated, you should wear a mask in public places.

Reference significance for asthma management in China

1.For the diagnosis of asthma in China, we should pay attention to the following points.

(1) It should be emphasized in medical institutions at all levels that the diagnosis of asthma should be based on the objective basis of symptoms and signs and variable airflow limitation.

(2) When the first symptoms appear, whether to carry out further examination should be decided according to its clinical urgency. If necessary, the lung function data or variable airflow limitation data should be recorded. For patients who have received treatment but have no asthma-related data records, relevant examinations should be improved according to their control situation.

2.In the evaluation of asthma control, use "mild asthma" cautiously.

The term "mild asthma" should be avoided in clinical practice. If necessary, patients with infrequent symptoms or mild asthma symptoms may still have severe or fatal attacks, and this risk can be reduced by half or even two-thirds by using low-dose ICS or low-dose ICS- formoterol as needed.

3.About the treatment and management of asthma

(1) Attention should be paid to individualization of treatment, and the treatment decision should take into account the characteristics or phenotypes of patients, which may predict the difference of treatment response between them and other asthma patients. In addition, the patient’s expectation of therapeutic effect, psychological burden and some practical problems (inhaler technology, compliance, ability to use drugs, patient’s cost, etc.) should also be considered.

(2) It should be emphasized that low-dose ICS- formoterol as a remission agent is the first choice for most people.

– END –

Medical institutions all over the country go all out to ensure medical treatment for patients.

Cctv news(News Network): In the past few days, medical institutions at all levels in various places have gone all out to do a good job in the advancement of diagnosis and treatment and the treatment of patients.

At present, the epidemic situation in Beijing has generally slowed down. In order to alleviate the pressure of treatment in secondary and tertiary hospitals, various community health service centers in Beijing have tried their best to improve their service capacity and provide oxygen filling services to residents in need. A total of 287 inpatient beds were added in 21 community health centers under the jurisdiction of Fengtai District, providing residents with in-patient treatment and other services nearby.

Shanghai co-ordinates medical resources and implements classified diagnosis and treatment. The city’s 249 community health service centers have formed a one-to-one cooperative relationship with 53 district-level hospitals and 17 municipal general hospitals.

Sichuan has implemented the responsibility system of lump-sum responsibility and established a three-level severe treatment system, covering 66 third-level hospitals and 287 district-level hospitals in 21 cities and prefectures in the province. At present, the utilization rates of total beds and severe beds in medical institutions above the second level are 88.91% and 64.87% respectively.

In-depth interpretation of 4K film experts: there is no timetable for promotion difficulties and popularization


 
  Special feature of 1905 film network The literary giant directed by Zhang Yimou has been shown in cinemas all over the country for some time, and made a special exhibition at the 67th Cannes International Film Festival. As the first film shot by a 4K camera, post-produced in 4K and released and shown in 4K in China, it can be said that Return fills the gap in domestic 4K movies. At the same time as the film was released, the concept of "4K", which is unfamiliar to most people, suddenly became hot. So what is a 4K movie? What is the current situation of 4K movies in the domestic market?
 
  The so-called 4K actually refers not only to technology, but also to a brand-new movie-watching experience, which is simply "higher, faster and better". "Higher" refers to movies with ultra-high definition quality, and the resolution of 4K digital movie pictures is 4096*2160. At present, the resolution of 2K projectors used by most cinemas in China can only reach 2048*1080. For ordinary viewers, the gap between them is equivalent to the gap between Blu-ray and DVD.
 
  "Faster" means higher frame rate. Because human eyes are less sensitive to high-speed motion, if you want to have the impression of ultra-high-definition movies when watching dynamic pictures, the movie pictures played per second must be increased from the current 24 frames per second to 60 frames. And "better" mainly means the promotion of the brightness and color of the film. Because the brightness of the 4K film is four times that of the 2K film, the details in the dark part of the picture are clearer, and the overall layering of the picture is strengthened, which can bring a more realistic viewing experience.
 
 


Hibernation, filmed with a 4K camera, won the Palme d ‘Or at the 67th Cannes Film Festival.
 

  Coincidentally, at the just-concluded 67th Cannes International Film Festival in France, Popular Desire, directed by the master Ceylon, won the Best Film Palme d ‘Or Award, which was also shot with a 4K camera. However, in an interview with the media, the director modestly revealed that he only shot in 4K with sponsorship, without any consideration from the perspective of film aesthetics — — The caution of film creators is actually closely related to the status quo of the entire 4K industrial chain.
 
  According to Xu Bin, the product strategy manager of China Film Barco, which was the first to sell and invest in 4K equipment in China, 4K technology and equipment are available now, but there are still difficulties in promotion: "This is actually a question of chicken or egg first."
 
  4K resolution can bring a better viewing experience to the audience, but it has encountered many difficulties in marketing. Due to the high equipment cost and the limitation of cinema hardware conditions, at present, only more than 600 cinemas in China have 4K projectors. The bottleneck of the downstream industry directly affects the development strategy of filmmakers: according to statistics, in 2012, the number of films shot by 4K cameras in the global film market was single digits, and in 2013, this number increased slightly to more than 20.
 
  The producer’s caution is not unreasonable. The shooting cost of a 4K movie is 150% of that of an ordinary 2K movie. In the post-production process, you must also use a projector with 4K resolution to color and repair the film. In order to show movies on the largest scale, publishers must also make two sets of digital copies, 2K and 4K. High investment in the whole industry chain can not bring high returns. This contradiction makes the promotion of 4K movies difficult.
 
  
 
  In an exclusive interview with [1905 Movie Network], Xu Bin said that the movie screen with 4K resolution is playing on the screen, and ordinary viewers can’t see the difference between 4K and 2K with naked eyes. This is because the biggest difference between 4K resolution and 2K resolution is only the reduction of picture particles, just like a film with low resolution, once the audience sits far away from the screen, they think the picture is very clear.
 
  In this way, the ordinary audience’s perceptual knowledge of 4K movies is not as strong as 2D to 3D and ordinary screen to IMAX from the beginning. This brings a problem to the cinema: if a 4K projector is purchased, the audience can’t recognize the improvement of picture clarity with their naked eyes, and the equipment funds can’t be recovered by raising the ticket price. For cinemas with box office revenue as the highest interest, 4K projectors are similar to "chicken ribs".
 

 
  Of course, for those cinemas that pursue the audience’s viewing experience, 4K projectors can be regarded as a long-term investment. Orange Sky Jiahe Cinema and Jinyi Cinema are the first commercial cinemas in China to purchase 4K projectors. Among them, Jiahe Cinema has purchased hundreds of 4K projectors since it signed a strategic agreement with Sony in 2011. At present, 40% cinemas in Jiahe Cinema in China are equipped with 4K projectors. Due to the lack of film sources, Jiahe Cinema has been playing movies with 2K resolution with 4K projectors for many years.
 
 
Dr. Xie Qiusheng, Chief Technology Officer of Orange Sky Jiahe Group, explains 4K projection technology.
 
  According to Dr. Xie Qiusheng, Chief Technology Officer of Orange Sky Jiahe Group, 4K projectors have a high demand for cinema hardware. Only on the big screen with a width of 16 meters to 25 meters can 4K movies show its delicate picture texture. At present, the screen with a width of 10-13 meters is the mainstream of domestic cinemas. From a technical point of view, giant screen is most suitable for showing the ultra-clear picture quality of 4K movies, but the number of giant screens is still very small.
 
  At the same time, Xu Bin also talked about the requirements of cinema hardware. The equipment with 4K resolution is different from ordinary 2D projection equipment, and the seats in the whole cinema need to be readjusted. The audience sitting in the front can feel the clarity and texture of the picture. The extra expenses for the renovation of cinemas have also discouraged some cinemas from 4 K.
 
 
  The high cost of 4K movies leads to the slow development of the whole industrial chain. According to reports, the film and television equipment suppliers represented by Sony, Barco and Secco have already introduced projection equipment with 4K resolution, but the sales volume of 4K projection equipment is far less than that of 2K equipment. In this regard, suppliers seem helpless. As a passive party in sales, equipment suppliers will provide technical support for cinemas from a long-term perspective-but cinemas can only choose and purchase projection equipment according to the ratio of return on investment and the cycle of capital recovery.
 
  In addition, due to technology monopoly, the film projection technology is in the hands of a few companies, and the projection level is promoted through exclusive cooperation between exhibitors and suppliers, but for the audience, it has long been confused by new words such as IMAX, DMAX, Real 3D, RealD 6FL, Panorama Auditorium and so on. Why can’t all advanced technologies be organically combined with one projection equipment? The cooperation between manufacturers may accelerate the progress of projection technology. In recent years, the world’s top film and television equipment manufacturers have begun to work together. According to Xu Bin, IMAX and Barco signed an exclusive commercial cooperation agreement. In the next seven years, Barco will provide IMAX with laser projection equipment with 4K resolution, and it will not be a problem to watch 4K on the giant screen in the future.

Next page "Return": Is the opportunity of popularization of 4K screening still a marketing gimmick?

 

COVID-19 epidemic+political virus, the US military is somewhat overwhelmed.

  Xinhua News Agency, Beijing, April 11 (Xinhua) In the face of the accelerated spread of the COVID-19 epidemic in the United States, Jerome Adams, director of the US Public Health Bureau, warned a week ago, "This will become our ‘ Pearl Harbor Moment ’ Or ‘ 9·11’ Moment. "

  What has attracted much attention is that the epidemic situation in the US military is fierce, and it seems that this "dangerous statement" can also be applied. Up to now, there have been confirmed cases in 150 military bases and 4 aircraft carriers, and the number of confirmed cases of active servicemen has exceeded 2,200.

COVID-19 epidemic+political virus, the US military is somewhat overwhelmed.

  On April 8, American soldiers walked past a hospital in new york, USA. Xinhua News Agency (photo by Guo Ke)

  Senior U.S. military officials said that the Covid-19 detection ability of the U.S. military still needs to be improved, and the number of confirmed cases in the U.S. military is expected to rise further.

  Why is this well-equipped huge army so passive in the face of the epidemic? Some analysts believe that the slow anti-epidemic and "political virus" are the dual causes.

  Pearl Harbor and West Point Military Academy were all recruited.

  According to the US media "Global News Weekly", at least 150 US military bases in 41 States in the United States have confirmed cases of COVID-19. Well-known military institutions and bases, such as Pearl Harbor, Norfolk Military Port, West Point Military Academy and the United States Naval Academy, have not been spared.

  According to the report, military bases in cities such as San Diego, Norfolk, Jacksonville and San Antonio are the most seriously affected, and Andrews Air Force Base near Washington, DC, has also received a large number of confirmed cases.

  In addition, confirmed cases were found on four aircraft carriers, including Roosevelt, Reagan, carl vinson and Nimitz, and the epidemic situation of Roosevelt was the most serious.

COVID-19 epidemic+political virus, the US military is somewhat overwhelmed.

  An American F/A-18 Super Hornet fighter flew over the aircraft carrier Roosevelt on February 27th. The picture is from the US Navy.

  According to the information released by John Heiten, vice chairman of the Joint Chiefs of Staff of the US Army, on April 9, local time, more than 400 US soldiers on this aircraft carrier tested positive for Covid-19, accounting for nearly 10% of all the officers and men on board.

  Heiten said that there was also a "small-scale outbreak" on the Nimitz aircraft carrier currently docked at the military port in Washington State.

  According to the data released by the Pentagon on April 10th, local time, a total of 2,209 Americans in active service tested positive for Covid-19, and one of them died.

  Insufficient detection ability

  Epidemic situation or continuous spread

  "Should not put ‘ Roosevelt ’ The no.1 incident is regarded as a special case, and it is necessary to plan ahead and prevent problems before they happen. " Heiten warned.

  On the 9th local time, U.S. Navy Operations Minister Gilday said: "Our challenge now is that we can’t carry out a large number of tests quickly. I don’t know when we can reach the level we hope. "

COVID-19 epidemic+political virus, the US military is somewhat overwhelmed.

  American soldiers transferred sailors from the Roosevelt on April 4. The picture is from the US Navy.

  It took only about one month from the publication of the first confirmed case to the cumulative number of cases exceeding 2,200.

  The Pentagon announced on March 7 that a marine who had just returned to the United States from overseas was diagnosed in Virginia. After that, the number of confirmed cases increased gradually, breaking through 100 cases on March 22nd, 1,000 cases on April 3rd and 2,000 cases on April 8th.

  Some analysts believe that there are two factors in the acceleration of the US military epidemic: First, in military bases and warships, the personnel density is high, and there is a lack of independent living places. A large number of soldiers need to share places such as work, living and dining. Second, the US military is deployed all over the world, and the flow of US military personnel is very frequent.

  "political virus"

  Contribute to the spread of the epidemic

  The American media reported that there is another factor for the rapid spread of the US military epidemic — — Some senior U.S. military personnel are infected with "political virus", which puts the so-called image of the U.S. military and superior preferences above the health of officers and men, resulting in slow response measures and delaying the opportunity to fight the epidemic.

  The "Roosevelt" storm that made a lot of noise a while ago is an example.

  On the way from Vietnam to Guam on March 22, the aircraft carrier Roosevelt found two confirmed cases on board. With the aggravation of the epidemic, crozet, the then captain, sent a distress letter to the top of the US military on March 30, saying that "the virus is spreading continuously and accelerating", hoping to arrange for the crew on board to disembark for treatment, detection and isolation as soon as possible.

  After this letter was exposed by the media, it immediately caused widespread reports. Modley, then acting secretary of the navy, dismissed crozet. He also argued afterwards that this letter "makes people think that the navy is ineffective in responding to the epidemic and the government is ineffective in responding to the epidemic."

COVID-19 epidemic+political virus, the US military is somewhat overwhelmed.

  Modley held a press conference at the Pentagon on April 2. The picture is from official website, the US Department of Defense.

  Crozet’s dismissal caused great waves in the United States. Many people think that his dismissal is a retaliation by the top US military.

  Doyle hodges, an American military expert, commented in an article: "When Modley announced the dismissal of crozet, he showed hypocrisy, incompetence and indifference to his subordinates."

  When crozet left the ship, a large number of officers and men shouted crozet’s name to pay tribute to him, and related videos were widely spread on social media. Crozet, who was in the eyes of the public opinion storm, also tested positive afterwards.

  The most ironic thing is that Modley, the US acting secretary of the navy who fired crozet, lectured the officers and men of the Roosevelt and criticized crozet for being "too naive" and "too stupid", but it caused public anger and ended up with an apology and resignation. (Reporter: Liu Yang; Editor: Sun Hao)

November SUV sales: Model Y is the first, and this "domestic product" takes the fuel sales crown.

November SUV sales: Model Y sold 44,000 units a month, and this "domestic product" won the fuel sales crown.

Just entering the middle of December, the sales volume in November arrived as scheduled. The retail sales volume in the domestic auto market reached 2.424 million vehicles, up by 16.6% and 7.2% respectively from the same period of last month, among which the sales volume in SUV market was 1.201 million vehicles, which was still the market segment with the highest proportion. At the same time, it still showed a strong growth momentum, up by 19.6% and 6.0% respectively from the same period of last month. From the performance of various models, the SUV market structure is changing, the proportion of new energy SUVs is higher than that of fuel, Tesla continues to win the first place, and the fuel SUV has won the first place, and the overall ranking has risen to the third place.

Tesla Model Y was the biggest winner in the SUV market in November, ranking first with sales of 44,576 units, leading the second-place PLUS by nearly 20,000 units. Compared with the same period of last year, the sales volume of Model Y decreased by 10.63%, but increased by 23.12% month-on-month. The year-on-year decline was due to the increase of competitors, while the month-on-month increase was more proof of the gold content of Model Y, which was excellent in both brand influence and product strength. Of course, the growth of Model Y is also due to the recent price reduction and preferential policies, coupled with the recent announcement of free battery replacement for some old cars. A series of measures have stimulated consumers’ enthusiasm for car purchase.

Under the strong leadership of Tesla Model Y, independent brands BYD and Geely also showed strong competitiveness. Among them, BYD PLUS ranked second with the sales volume of 26,400 vehicles. The new car has a reliable three-electric system and high cost performance, which has won the favor of consumers. In addition to Yuan PLUS, BYD Song L DM, Song PLUS DM, Yuan UP and Song Pro DM have also entered the top 15, on the one hand, the general trend of electrification, on the other hand, BYD’s first-Mover advantage and technical strength, etc., and have achieved good results in various market segments.

BYD Yuan PLUS won the new energy SUV sales crown of its own brand, while Geely Xingyue L was the best-selling fuel SUV sales crown, with 24,667 vehicles sold in November. The appearance of the new car is young and sporty, and the interior is a rare model with three large screens at the same price. As for the core three parts, there are 1.5T and 2.0T options, of which the 2.0T version is equipped with Volvo engine and Aixin 8AT, which leads the same level in driving experience, and therefore stands out in the fuel SUV market. In addition to Geely Xingyue L, Changan CS75 PLUS and Tiggo 8 are also on the list. These independent brand models have successfully occupied a place in the SUV market with their excellent quality, rich configuration and reasonable price strategy.

At the same time, the joint venture brand SUV is also facing increasing competitive pressure. Although joint-venture brand SUVs including Toyota RAV4 Rongfang, Toyota Corolla Ruifang, Volkswagen Tiguan L and Honda CR-V still maintain a high sales level, they have entered the top 15 SUV rankings, but the overall ranking is lower, and the best-selling RAV4 Rongfang is only ranked 10th, and it is also the only joint-venture SUV model with sales volume exceeding 20,000.

In addition to the frustration of ordinary joint venture brand SUV, the performance of luxury joint venture brand SUV is also poor. Even though a large discount has been given recently, no model has entered the top 20. From the list, there are also models with an average price of over 250,000, but they all come from independent brands, namely Ideal L6 and Wenjie M9, with sales of 24,318 and 16,409 respectively in November. This is mainly due to the rise of self-owned brand SUV and the change of consumers’ concept of car purchase. More and more consumers begin to pay attention to cost performance and personalized needs, and self-owned brand SUV just meets these needs.

Judging from the SUV sales ranking in November, the competition is fierce, and the top 15 models and rankings are changing. What remains unchanged is that new energy vehicles have maintained a strong growth momentum. With the continuous progress of new energy vehicle technology and the improvement of charging facilities, the share of new energy vehicles in the SUV market will gradually increase. From the brand point of view, independent brands have performed amazingly in the SUV market, accounting for more than joint ventures. In the latest catalogue of the Ministry of Industry and Information Technology, there is already a large wave of independent heavy new cars ready to go. It is foreseeable that the next SUV market will remain strong, but the competition will also intensify. However, for consumers, there are indeed more good choices, and according to the current competitive situation, the price estimate will also have surprises.

Analysis of 08 Land Rover Range Rover Sport Edition

  Range Rover Sport Edition originated from Land Rover’s first concept car, Range Rover Storm, which debuted at Detroit Auto Show in January, 2004. Land Rover Sport Edition is the first time that Land Rover combines the vitality of sports cars with the orthodox identity of Range Rover, showing a kind of strength and style brought by the shock of all-round sports performance and real off-road authority, and has become the fifth brand of Land Rover family.

  Range Rover Sport Edition is a real "sport station wagon", which fully provides the road performance required by sports cars, excellent handling and greatly improved acceleration performance. 0-100km/h takes only 8.9 seconds. A series of dynamic control systems such as DSC and CRM ensure excellent control performance; At the same time, it ensures the comfort of long-distance driving and riding. The Range Rover Sport Edition has a special feature. The second row of seats can be folded down to form a plane with the trunk, which not only greatly increases the storage space of the trunk, but also can be used as a temporary bed in long-distance travel.

  Smooth shape, hood curve and tail spoiler, drag coefficient is 0.36. The flowing design conveys the sense of movement and performance. Range Rover Sport Edition has a distinct personality and a sense of movement, which changes the traditional castle-like shape design of Land Rover, selects a suspended roof with a larger slope, and gives it more "sports" shapes with a unique tailgate design. In order to highlight the sports characteristics of this car and improve its agility, its wheelbase is shortened by 13.5 cm compared with the Range Rover.

  Range Rover Sport Edition not only maintains Land Rover’s unique commanding vision, but also adds a racing cockpit feeling. The towering central console, the driver’s new shift design, and the sports package seat that sits in it instead of sitting on it. The perfect LOGIC-7 surround sound system, with two independent display screens in the back row, 7.1 digital surround sound and 14 speakers, creates a vivid 3D feeling for drivers and passengers during long-distance driving.

  It has a 4.4-liter naturally aspirated 32-valve four-camshaft V8 engine which originated from Jaguar and was carefully improved by Land Rover. It can output 300 horsepower (220 kW) at a speed of 5,500 rpm and 425 Nm of maximum torque at a speed of 4,000 rpm. A variable camshaft timing system is also adopted, which can automatically control the valve timing according to the driving action. Power and torque are transmitted to all four wheels anytime and anywhere through the advanced ZF6-speed electronic control automatic gearbox, which ensures smooth shifting operation and super-class throttle response.

  高强度车身,较低的重心和能吸收大量能量的馈缩区可为乘客提供保护。电子防侧倾系统(ARM)会监控车辆的稳定性。车身动态稳定控制系统(DSC)则可监控车轮速度和转向角度,使转向操作更安全,更稳定。车身动态稳定控制系统将ABS制动力应用于单个的车轮上,以提高对车辆的控制。让人更加放心的是,路虎揽胜运动版还装配了8个安全气囊,包括侧面帘式安全气囊。

  揽胜运动版的越野性能还借助全地形反馈适应系统得到进一步的提高。驾驶者只需转动中央控制旋钮即可轻松选择五种地形模式:普通路面模式,光滑路面模式(即草地/砾石/雪地),和三种特殊路面模式(泥泞/车辙、沙地和岩石路面),全地形反馈适应系统则自动对汽车的牵引与动力系统进行优化,以适应具体的路面情况。拥有此系统,驾驶者无论是越野高手还是经验稍逊的越野爱好者都可以信心十足地挑战自己的越野极限。揽胜运动版的电子空气悬挂系统具有自动负荷平衡功能,即在实际使用过程中该系统可根据车内各方向承重自动调节,以确保车身平衡,能够提供强大的公路驾驶性能与不错的越野性能。(石文夫)