标签归档 南京龙凤1314

Geely xingyue l power exposure is equipped with Volvo’s same 2.0T engine.

Geely xingyue l is equipped with Volvo Drive-E 2.0TD engine and offers 2.0TD-T4 EVO and 2.0TD-T5. At the same time, it also won the title of "Top Ten Engines of Ward" for three consecutive years.

introduction

A few days ago, Netcom got Geely’s new SUV-Xingyue L power information. The new car will be equipped with Volvo Drive-E 2.0TD engine, which is divided into 2.0TD-T4 EVO and 2.0TD-T5. It is understood that Xingyue L is the flagship SUV model under the CMA super matrix structure jointly developed by Geely and Volvo.

Hefei net

Hefei net

In terms of power, the Drive-E 2.0TD mid-range direct injection turbocharged engine provides high and low power. The maximum power is 160kW and 175kW respectively, and the peak torque is 325N·m and 350N·m respectively, which matches Aisin 8AT gearbox. The engine is made of all-aluminum and has obvious advantages in light weight, low fuel consumption and NVH. It has been widely used in Volvo XC90, Volvo S90, Lectra 03, Lectra 03+and Lectra 05.

Hefei net

Hefei net

In terms of appearance, the iconic straight waterfall air intake grille on the front face of Xingyue L is decorated with chrome trim strips and matched with Geely black LOGO to enhance the sense of grade. In addition, the headlights and grille of the car form a very impactful front face shape, which is more domineering with the large air intakes on both sides of the bumper.

Hefei net

Hefei net

The overall profile of the new car side is very tough, and the smooth waistline runs from the headlights to the taillights, which enhances the three-dimensional sense of the whole side and contains the ultimate strength in the movement. In terms of size, the length, width and height of the new car are 4770/1895/1689mm and the wheelbase is 2845 mm. At the rear of the car, Xingyue L adopts the popular penetrating taillights to stretch the width of the rear of the car visually.

Hefei net

In terms of interior, Xingyue L adopts a brand-new design concept and luxurious technology configuration. The overall interior uses a simple style and integrates oriental aesthetic elements. The center console adopts a double-color design, which spans the entire center console’s super-large three-screen and integrates the dashboard, the central control screen and the co-pilot entertainment screen. The central control screen and the co-pilot entertainment screen are 1 meter long, showing a full sense of technology as a whole. It is reported that Xingyue L will be equipped with Geely’s latest digital intelligent cockpit system and higher-level autonomous driving technology.

(Photo/Text Netcom Zhang Jingkai)

A guide to love movies | Talk about a sweet love in the cinema.


Special feature of 1905 film network On February 14th, 2022, five love movies were released in line. Except for two re-released movies, the popularity of the other three new movies continued to increase. By 8: 00 pm on the 14th, the box office broke through 100 million, winning the box office champion of the day, 60 million and 40 million. Three movies performed strongly and all entered the top five in today’s box office list. Which of these will be the audience’s favorite? When buying tickets, what qualities do the audience value more about love movies?


The program was interviewed at random, and an audience said with a smile: "Under normal circumstances, we have no initiative to buy tickets. However, if you choose it yourself, you may choose "Ten Years of Temperament". " Another viewer chose: "I prefer to see something happy and positive in love movies." One viewer thinks: "I like romantic movies that are funny."

There are also viewers who value the actor Cass: "If you love movies, you can watch actors. If I like them better, I may go and see them." And the audience decided to watch the title of the film: "I really want to go to your world and love you" is very attractive to me. " An audience member thinks that emotional resonance is very important: "Whether it is crying or funny, it can let emotions vent."



It is not difficult to see through interviews that love movies are really just needed by the audience to watch movies. At such a romantic moment, Ni Jun, an associate professor at the Central Academy of Drama, used three key words to sort out the three love movies released today: "Ten years of gentle words is love trapped in time," I really want to go to your world and love you "is love trapped in space, and" Don’t forget I love you "is love trapped in memory."



Judging from the film titles, the names of love movies are getting longer and longer, such as "I really hate long-distance relationships", which are long and awkward, but the titles of the three films released today have clearly expressed the stories to the audience.

"Wen" in "Ten Years’ Taste as Warm as Words" refers to the heroine Wenny, "Yan" is the hero Dj Yan, and "Ten Years’ Taste" points out that the story focuses on ten years of nostalgic love; "I really want to go to your world and love you" clearly tells your audience that the hero and heroine are not together, so I want to go to your world and love you, pointing out such regrets; "Don’t forget I love you" highlights the theme with the word "forget": amnesia.


Ten years’ taste is as warm as words

"Brother and Sister" Love Spanning Ten Years


Although the themes of the three films are different, because they are all love-themed films, will their promotional materials give the audience the same feeling? With a little nostalgic feeling, "Ten Years’ Taste as Warm as Words" tells the story of "brother and sister" love that spans ten years. The brother and sister are not related by blood, which stems from the complicated adoption and foster care of two families. Ni Jun said: "It is a traditional love story with a sweet and abusive text in 2009. Because of this decade of silence and a very realistic life blessing, I think this is its characteristic."


I really want to go to your world and love you

Fantasy love in a different place, but with synaesthesia.


"I really want to go to your world and love you" is not quite the same as the usual love movie. The material is the big photos of two people stuck together, which is very sweet, which is in contrast with the movie, because they are always separated from Wan Li in space, although they are in different places, but their brain waves are interlinked. The addition of this fantastic element of synaesthesia has made many viewers look forward to it. How to talk about this love will be the reason for many people to enter the cinema.


Don’t forget I love you

How to renovate the common theme of amnesia


The story "Don’t forget I love you" focuses on amnesia, and the poster contains the daily polaroid of the protagonist. Combined with the theme, it is likely to be a prop to wake up amnesia. Through photos, the protagonist should remember who the other person is every day and remember that they loved each other. Ni Jun mentioned: "In this year’s variety show,’ Hao Shi is in pairs’, and they also played a love story of amnesia. I think it depends on how the current film is refurbished. I have this expectation. "


Ten years’ taste is as warm as words

A film for fans of original books.


So which part of people are suitable for these three films to watch accordingly? "Ten Years of Taste as Warm as Words" gives people the feeling that it is for the original book fans. I read this book in my youth and want to see if the male and female protagonists are still so in love after ten years. Ni Jun said: "Dj Yan is a perfect boy in the original work; It is the 2016 class of our school. She made a lot of movies during her school days, which is very close to the characters in the original book. "


I really want to go to your world and love you

The best choice for long-distance love


"I really want to go to your world and love you" also features two cutting-edge actors, the modest gentleman in "I want to see you" and the strong jiao in "The Sky of Wind Dog Boys". Zhou still gave people the impression that she was a very boyish girl before. Now it is a sense of contrast to let her play the heroine of a love movie, because she has added fantasy elements.

There are many successful cases of the collision between love and fantasy, such as 2017, 2018, 2020, 2021, etc., which have achieved very good reputation and box office. Ni Jun added: "The film has a concept of long-distance love, so I wonder if there are also many long-distance friends who choose a movie together and then use such brainwaves to communicate."


Don’t forget I love you

A good medicine for curing love


The harmony in Don’t Forget I Love You is older than the male and female protagonists in the previous two films, and more like a slightly mature love. The film is likely to attract many people who need to be cured in love. Couples may have a little awkwardness. Even when thinking about whether this love should continue, let’s watch this film together and learn how to make each other continue to fall in love with themselves. The film is probably a good medicine for love, with healing function.


On the extremely romantic February 14th, many couples walked into the cinema and chose a love movie, so that the off-screen love and the on-screen love could complement each other and talk about a sweet love. Just as the love movies shown in the cinema are different at the moment, love has various forms. May couples all over the world enjoy the sweetness brought by different love in the warm atmosphere of the cinema.


The "Wang Wang Team’s Great Movie" is scheduled to be released on January 14th.


1905 movie network news The official announcement of the first big movie of the well-known animation IP "Wang Wang Team made great contributions" was released nationwide on January 14, 2022, and a 2D version of Chinese dubbing came simultaneously. The film 3-day weekend, the first in North America, earned more than $13 million at the box office, and won the North American animated film box office week champion. Not only that, the Wang Wang team also made great contributions in word of mouth. At present, the film’s freshness of rotten tomatoes is as high as 79%, which is deeply loved by parents and children all over the world.

The film tells the story that after Haidina, who has always been famous for destroying the city, became the mayor, it added new troubles to Adventure Bay! The urban track transformed into a roller coaster, the excessive fireworks at the inauguration ceremony, and a series of new plans to destroy the city are brewing. The dogs of Wang Wang Team, led by Captain Ryder, came to the city center, moved into the new headquarters building, and prepared for greater challenges with brand-new upgraded weapons and equipment. This time, the Wang Wang team ushered in a brand-new ally, Beibei Dachshund, to participate in the rescue of Adventure Bay! Team Wang Wang set out for rescue!

It is worth mentioning that the overall upgrade of the film in terms of production quality and story is beyond expectations. In the plot, in addition to the addition of new friends, the new headquarters building with a more scientific sense appeared for the first time, which made the children climax in the process of watching movies. In the preview, the fully automatic mechanical arm helps dogs to wear high-tech equipment, helicopters and rescue vehicles that can be transformed again, making the members of the Wang Wang team become super agents to save the world. In production, the naked eye can see the dog hair production full of details, and the big scenes created under the crisis of the whole metropolis all make the audience look forward to the film.

As a super-popular children’s IP that is popular all over the world, the series of animations of "Wang Wang Team Makes Great Achievements" has been enthusiastically sought after by parents and children all over the world once it is launched. Since this series of animated series was introduced into China in 2015, it has been launched on major video websites one after another and achieved a high click-through rate, which is well known and loved by more and more children. "There are no difficult jobs, only brave dogs", this familiar slogan has also become the mantra of children nowadays. After the first big movie was released overseas, it won a lot of praise. Many media and film critics praised it: "If you have children, you must watch the Wang Wang team!" .

Others said that the feeling of watching movies is excellent: "Happy, cheerful and sincere, the children will definitely fall in love!" . When the film released the introduction news, it attracted the attention of the majority of family audiences. They all said that the children should never miss the first big screen adventure of the Wang Wang team.


Random talk on the "unreliable" love of British royal family Diana

Original Ye Er Republic of China woman

First, she "loves" the prince, and the prince loves another person.

In the inspirational version, Diana is portrayed as Cinderella in a pumpkin cart. In fact, her family background is very good. Her father is Count Spencer, and her family has always been closely related to the royal family.

The first date with Charles was not Diana, but Diana’s sister Sarah. Sarah is smart, confident and radiant. She is closer to Charles in age and mind.

Because of this, she has no respect and admiration for Charles, but associates with Charles with the mentality of lovers. From the lover’s point of view, Charles is not a good candidate. He is sensitive and insecure, and he is eager for others to give him emotional input, but he will not give others emotional output.

Charles likes Camilla, who is complementary to his personality, because Camilla is warm, confident, humorous and can export her feelings to him. However, Camilla was not a virgin, and the royal family did not agree to their marriage. Camilla married someone else, and Charles was inseparable and had to choose another spouse.

Diana in Salabi is intelligent, mature and strong in heart. If she marries Charles, it is possible to pull Charles’ heart away from Camilla. But Charles and Sarah didn’t look at each other right, and because of some misunderstanding, they didn’t talk about it.

Charles took an interest in Diana.

Diana was pure and shy, and Charles was attracted by her. For Diana, the countess, she doesn’t go to school now, and she doesn’t have to worry about the source of life. She teaches children to dance for a week without a few classes, and the spiritual emptiness is just filled by love.

Although Charles is stuffy and boring, he is a prince. Whoever marries him will be the Princess of Wales and the future queen. Diana couldn’t resist the temptation.

Diana thought she was in love with Charles, but in fact she loved the identity of a prince, an imaginary love fairy tale. Charles doesn’t love Diana, but a innocence he lost, an innocent body suitable for being a princess.

Two people, each with his own needs, were married.

As expected, after their marriage, they had conflicts and quarrels, and Charles turned to Camilla to appease the "injured" heart. Diana also went to find a lover, but the lover she found in a hurry was of worrying quality, which could not soothe the pain in her heart. She summoned up the courage to tell the TV station that "there are three people in her marriage, which is too crowded", causing public outcry.

Her marriage to Charles came to an end.

Second, the marriage failed, and Diana kept trying and making mistakes on the road of love.

Both Charles and Diana were born in nobility, and nobles are human beings, and they are also eager for love and happy marriage. However, unlike ordinary people, nobles have a lot of property and slaves, and they have a wider detour space. If they are properly used, they can avoid many contradictions.

The old countess in Downton Abbey said a sentence to the effect that "a noble marriage can’t be unhappy". She didn’t explain the meaning of this sentence. I think so-ordinary couples, living under one roof, daily necessities, old people and children, bumping into each other, contradictions are inevitable.

Nobles have manors, servants, children are transported by servants, and old people are taken care of by servants. Two people are tired of watching it. You live in yours, I live in mine, you play with yours and I play with mine. It’s just that in the scene, two people come out to socialize together.

Therefore, in the traditional western upper class, the phenomenon of lovers is widespread. Husband and wife are tired of seeing each other, so they can get emotional supplement, avoid the imbalance of interests caused by divorce, and turn a blind eye to illegitimate children.

After the rekindling of the old love between Charles and Camilla, Diana began to look for a lover in order to get back at Charles and relieve her loneliness.

The rabbit eats grass by the nest first, and Diana’s first lover is her bodyguard. Their love affair caused gossip in the palace, and the bodyguard was fired. Later, the bodyguard was killed in a motorcycle accident.

Around the birth of Prince Harry, Diana fell in love with equestrian coach Hewitt. Hewitt is a playboy, and a playboy knows how to please women. Diana wrote many love letters to Hewitt, expressing her willingness to have children for Hewitt.

But Diana’s true feelings were paid by mistake.

Hewitt is a scum, profligate, and when he is short of money, he wants to exchange his relationship with Diana for money. He published a book "The Princess in Love", made his love affair with Diana public, and wanted to auction the love letter written by Diana to him. In order to get a good price, he revealed to the buyer that the content of the love letter written by Diana was "very exciting". Unexpectedly, the buyer is a reporter posing. When the news got out, he had to give up the idea of auctioning love letters.

Hewitt is also going to be on TV to tell his story with Diana.

Hewitt’s action put Diana in a passive position, and because of the provocation of BBC reporters, Diana decided to strike first and tell the TV audience about her failed marriage. This interview led to the disintegration of Diana’s marriage with Charles.

In the late 1980s, Diana fell in love with a car salesman. The car salesman is not handsome, but he has high emotional intelligence, sweet words and is good at deceiving people. He and Diana often make out on the phone. Their phone conversation was recorded by paparazzi, and it broke out. Diana broke up with the salesman.

In the early 1990s, Diana fell in love with an Islamic art dealer. The dealer’s wife found out about their relationship and put pressure on her husband. After careful consideration, the dealer decided to break off the relationship with Diana.

Diana was heartbroken. It is said that she called the dealer more than 300 times on the night of breaking up. The dealer was determined to return to her family and did not answer her phone.

Diana also fell in love with a billionaire who is 20 years older than her and a young rugby player. Her intimacy with football players made the players’ wives very unhappy.

After Diana died in a car accident, a royal housekeeper revealed that he had an affair with Diana. Diana often invited him over at midnight and they had sex. It was also revealed that Diana had an affair with Kennedy Jr. Neither of these things is true or false.

In 1995, Diana visited a friend who had a heart operation and met Hasnat Khan, a Pakistani-born heart surgeon. In Diana’s eyes, Hasnat Khan is a "Mr. Perfect". After Diana divorced Charles, she wanted to marry the doctor, but the doctor’s parents did not agree to their son’s marriage because of their different living habits and growing environment. The doctor didn’t want to be chased by people every day, so he refused Diana.

Diana was sad and disappointed, and turned to meet Dodi, the son of Egyptian rich Fayyad. Many people describe Dodi as an infatuated person who has been infatuated with Diana for many years. In fact, Dodi is a playboy. Before he fell in love with Diana, he had a girlfriend. His relationship with Diana was probably arranged by his father, Fayyad Sr.

Diana’s tryst with Dodi was originally intended to stimulate Hasnat Khan to see if he was jealous of his new relationship. Because Dodi and Diana died together, people deliberately beautified their love, which made many people have the illusion that Diana found true love at the end of her life.

3. Diana has never loved or been loved by the right person in her life.

Diana was a loveless child since she was a child. She felt inferior inside and longed for love. Inferiority makes her "love" Charles, and Charles can give her a dazzling aura of a princess. After the lack of love made her disappointed with Charles, she sought emotional sustenance again and again.

Diana was only sixteen years old when she was in contact with Charles, and she had almost no life experience. She had a hard time studying, and the only book she liked to read was Barbara Cartland’s romance novels. These Qiong Yao-style romance novels not only didn’t help her solve the marriage dilemma, but made her have unrealistic fantasies about love.

She has never fallen in love with a person because of the same three views. She only fell in love with a "feeling". She "loves" anyone who makes her feel novel and interesting.

Diana falls in love with people who are different from her.

Have a plenty of class gap, such as car salesmen and others, she is a noble, they are civilians.

There are some age gaps, such as the billionaire who is 20 years older than her.

Some are different from her religious beliefs, such as Pakistani doctors and Dodi, the son of Egyptian rich men.

It’s not that people who have a gap can’t fall in love and get married. The legendary love in the world-the prince and Cinderella, and the eighteen years of Wang Baochuan Cold Kiln, all have a gap.

But the gap means more difficulties and challenges, and people in love need more tolerance, courage, wisdom and means …

Diana lacks all these things.

On the surface, Diana wants to marry a Pakistani doctor because the doctor is a "Mr. Perfect" and dates Dodi, the son of a wealthy Egyptian, because Dodi is after her. In fact, she is probably in love with their exotic customs. After marriage, the mystery fades. How to face the differences between living habits and religious customs? Diana probably didn’t think about it.

Her eldest son, William, will inherit the throne in the future. According to tradition, the king of England is also the head of the Anglican Church. What inconvenience will William and his stepfather bring in their communication in the future? How can she help her son and husband to restrain this inconvenience? She probably didn’t think about it.

It is not surprising that a person has once or twice unreliable love in his life. Everyone grows up through trial and error, which is the price paid on the way to trial and error.

But the love in a person’s life is always unreliable, which is his or her cognitive problem.

Diana followed her feelings all her life, which led to the inhumanity she met in her life. In time, her heart will settle down, maybe her love concept will mature, but she died too early to wait for that day.

Author: Ye Er: I love fireworks and gossip.

Original title: "Talking about the" unreliable "love of the British royal family ∣ Diana"

Read the original text

In 2023, three important answers to medical and health money.

2023 is the year of recovery, but it will not reproduce the "madness" of 2019.

Text | Caijing reporter Zhao Tianyu Ling Xin

Edit | Wang Xiao

"There are several interesting projects. Once New Year’s Day is over, the negotiations will go smoothly." Zhang Chen, a partner of Probe Capital, said.

In 2023, many investors who pay attention to the medical and health field found that things began to develop in a good direction. According to the incomplete statistics of Caijing reporters, the opening year is only one month, and as of February 6, the total number of medical and health investment and financing has exceeded 50.

Together with Zhang Chen, many investors are willing to believe that the first half of 2023 will definitely increase, and it will be good, and the secondary market will be good.

Sequoia China predicted that,Investment and financing behavior will accelerate in 2023, because some investors feel that the market price has been adjusted back to a certain stage and are considering whether it is time to take the shot.

In the medical and health industry, what opportunities will appear in 2023?

"Oncolytic virus is a hot spot this year." In early January, Tang Haofu, a partner of Shanghai Chuangrui Fund and Chongqing Dianshi Chuangjian Fund, went to San Francisco to attend the J.P. Morgan Healthcare Conference in JPMorgan Chase, which was one of the trends he observed. JPMorgan Chase Medical and Health Conference, the largest and most informative medical investment seminar in the world, has become the vane of the global medical and health industry once a year.

Oncolytic virus is a kind of virus that can cause cancer cell apoptosis after being integrated into cancer cells, while keeping normal tissues from being destroyed, and can deal with different types and stages of tumors. After nearly 30 years of verification, it has become an important branch of tumor immunotherapy. In 2015, the US Food and Drug Administration (FDA) approved the marketing of oncolytic virus product Imlygic (T-Vec), which treats melanoma by intratumoral injection.

From the medical and health conference in JPMorgan Chase in 2023, small nucleic acid drugs, adeno-associated virus vectors (AAV) and new drug-carrying technologies of liposomes are also hot directions.

For small molecule drugs and antibody drugs, it will be better to have innovative targets. Although the new use of old drugs in oral medicine in COVID-19 was very successful, only one indication was changed, which was not well received at the meeting.

In the field of cell therapy, the fourth generation CAR-T has attracted much attention and has become the mainstream overseas. As for the targets that many local companies are still doing, such as CAR-T therapy targeting CD19 and CD22, few people abroad have done it.

In Tang Haofu’s view, cytokine storm, the number one risk factor in the clinical application of CAR-T therapy, is expected to be significantly reduced in the next three years. CAR-T therapy is mainly used for tumor treatment. Although this technology can remove tumor cells, it will also produce toxic side effects, that is, cytokine storm, by attacking normal cells in the body.

Tang Haofu looked at some projects and found that everyone was doing it in this direction. For example, Elpis, whose core team is from Harvard Medical School, has reduced its data cytokine storm by more than 70%.

In the field of cell and gene therapy (CGT), in 2023, many investors expressed their continued optimism.

Li Yishi, senior partner of Haoyue Capital, said,Cell therapy drugs, for a period of time, are mostly used for back-line patients, that is, those patients who have been resistant to most existing therapies.

The back-end market is relatively small, so it is unlikely to produce a large variety of drugs with sales of 1 billion yuan.

"If you want to say that there is an opportunity, it has to be this kind-if everyone has an opportunity, it is sunny, is it still an opportunity?" Li Yishi said.

As for gene therapy, Li Yishi said that at present, the whole field is dominated by rare diseases, and going to sea is the main commercial path.

"Gold digger" may not be successful, "water seller" still has a chance, but the field has been very subdivided.Zhang Chen is concerned about the mRNA in the direction of tumors and infectious diseases. He thinks that in this industrial chain, the opportunity of "selling water" is the best, such as making cell culture medium, and then looking further, transfecting reagents.

"We want to find some powerful companies and stay with them all the time. If we serve an infrastructure, it will become a profitable position." Zhang Chen said.

He is also optimistic about the opportunities of proteomics and structural biology. The demand for proteomics is increasing, and the financing in China market is accelerating; The contribution of structural biology to pharmacy may appear in the next year or two, especially the continuation of structural biology based on cryoelectron microscopy.

In terms of innovative instruments, Sequoia China said that it would pay attention to globally synchronized cutting-edge technologies such as single cell sequencing and single molecule protein detection.

Some investors favor gene sequencer. Zhang Chen said,At present, there is still room for improvement in mainstream machines. If the signal and noise can be well distinguished, early tumor screening will be more available. Hospitals require high detection speed, which requires machines with more flexible throughput, and the most important thing is the innovation at the bottom of sequencing.

It has been three years since the epidemic, and the detection in Covid-19 has fluctuated greatly. Both nucleic acid detection and antigen detection are betting on a policy window period, which leads to the concern of IVD (in vitro diagnosis) industry. Zhang Chen said frankly that because he was not sure what products would sell well in the future, he chose to look upstream.

Cardiovascular, neurosurgery, orthopedics and ophthalmology are the departments frequently mentioned by investors.

Although cardiovascular and orthopedics have been targeted by the national centralized procurement, they are still the departments that bring the most cash flow to hospitals, and the consumption of consumables is large and the demand is large, which promotes the emergence of new technologies and materials.

How to make doctors more labor-saving is a big product direction. Zhang Chen pays attention to small active medical devices (plugged in) and hopes that the higher the intelligence and complexity, the better.

Some instruments used in departments such as gastroenterology and cardiology will continue to develop into software and nano-scale miniaturized products. Interventional robots and interventional materials are the highlights.

Tang Haofu observed at the JPMorgan Chase Medical and Health Conference,The interventional robot is taking the route of miniaturization and software, and it is expected that there will be some progress in one or two years. There is also a self-driven gastrointestinal mirror, which is driven by its own propeller, and its technical content is much higher than before.

As for the open surgical robot, it is not a big focus in the short term. The typical product in this field is Da Vinci surgical robot, which consists of three parts: surgeon console, bedside manipulator system and imaging system. By enlarging the field of vision and defibrillating the hand, it helps doctors to complete the operation and reduce the trauma caused by the operation to patients.

Some companies continue to optimize this kind of surgical robot with different structures, but in the eyes of investors, it is "too heavy" and some actions are quite barbaric and not smart enough to operate.

Although surgical robots are not so popular, xenotransplantation, in Tang Haofu’s view, will become a hot investment in two or three years.

In 2022, the Medical College of the University of Maryland transplanted a pig heart to a 57-year-old man. In a few weeks after the operation, the transplanted heart in his body worked well and showed no signs of rejection. It lasted for 63 days until the illness deteriorated and died. This is regarded as a major breakthrough in the field of xenotransplantation, and it is expected that there will be companies mainly engaged in xenotransplantation within two years.

Hou Xuchao, founding partner of Zhuozhi Consulting, proposed that,There are three factors to grasp the opportunity of the industry: breakthrough and development in technology; The market demand and unmet demand are huge; It can improve the performance-to-price ratio or efficiency at some levels.

For 2023, "recovery" is felt by many investors, although the degree is different.

Hou Xuchao believes that on the whole, there will be a great recovery in 2023, but the "madness" in 2019 should not reappear. At present, the overall fund-raising form and exit channels have changed greatly, and the investment strategy and style of private equity funds have also changed greatly, so there will be new local hot spots and explosions, but it will not "raise chickens and dogs to heaven."

Sequoia China observed that,In fact, since October 2022, the biomedical industry has entered a slow recovery process, especially for companies with good fundamentals, and they have also seen many positive improvements.

However, after four years of epidemic tempering, investors’ mentality has become more cautious, the overall investment action has slowed down, and the difficulty of raising funds for companies in the market has also increased.

Li Yishi told Caijing reporter,For the heat of investment and the possibility of financing in 2023, it should be a tentative spiral upward trend.

For the key words in the field of health in 2023, Sequoia China is still an "early investment".

In the past few years, the capital market has made great strides, and the valuations of many primary market companies have soared. For investment institutions, if the investment is not early enough, the multiple of return may decline. From this dimension,In fact, all funds will gradually realize that whether it is active choice or passive choice, it is an inevitable trend to invest early.

Hou Xuchao’s key words are "innovation, efficiency improvement and cost performance". The medical and health field has returned to normal, and the industry continues to emphasize the value of innovation and technology.

Tang Haofu believes that the key word in 2023 is "deep innovation". With the opening of information channels, the communication between investors and overseas countries is getting smoother and smoother, and deep innovation will be valued.

Zhang Chen’s first thought is to consider long-term value, and new technology is the focus.

In Li Yishi’s view, "restart" is the key, and 2023 should be regarded as the first year of real departure after restart.

However, a private equity person in the secondary market said that in the short term of 2023, there are still uncertainties and there is no particularly clear conclusion. In the long run, we are still optimistic about China’s health field, because the problem of aging is more and more prominent, and we spend more on health expenditure.

Alas! Sterling won 11 championships in Manchester City in 7 years, and suffered nothing in his first season when he moved to Chelsea.

Live on May 21 ST, Manchester City, which won the championship three times in advance, will face Chelsea at home at 23:00 tonight, and Sterling will face the old owner.

Last summer, Sterling moved from Manchester City to Chelsea for a total fee of 55 million pounds.

Sterling joined Manchester City from Liverpool in July 2015. During his seven years in Manchester City, he scored 131 goals in 339 appearances and won 11 championships, achieving a grand slam in England.

Premier League Champion X4: 2018/2019/2021/2022

FA Cup X1: 2019

League Cup X5: 2016/2018/2019/2020/2021

Community Shield Cup X1: 2019

The first gene platform of polymer materials in China was born, which is called "ChatGPT of polymer version".

The key bottleneck restricting the development of advanced equipment is to meet the requirements of advanced resin composite materials with high strength, high temperature resistance and light weight. At present, such a difficult problem is expected to be solved. The reporter learned from East China University of Science and Technology that the first domestic polymer material genome research and development platform (AI plus polymer software platform) developed by Professor Lin Jiaping’s team was recently released in Shanghai.

The software is called "polymer version of ChatGPT", which contains the first database of resin structure and properties and chemical reaction between groups in China. Users only need to input the resin structure, they can quickly obtain its mechanical, thermal and dielectric properties, and can also make performance prediction and high-throughput screening through this software, so as to develop high-performance polymers and their composites with faster efficiency and lower cost.

"The research and development of new materials has entered the era of intelligent manufacturing from the era of trial and error of scientists." Lin Jiaping introduced that in the past, it often took 2-3 years or even longer for a new material to go from design, experiment to productization. Now, relying on this "polymer virtual laboratory", R&D personnel can find the optimal solution of structural design and formula optimization only through 2-3 iterations, and the experimental time is greatly reduced. The team will join hands with the industry to promote the development of AI plus polymer research paradigm to the whole industry chain.

Powerful database and forecasting system lead the industry.

What are the highlights of the AI plus polymer software platform? Lin Jiaping introduced that as an important achievement in the cross field of AI and digital technology and polymer materials, a powerful database is an important support of the platform and can be described as the cornerstone of material genetic engineering. The first database of resin structure and properties and chemical reaction between groups established by the team in China contains nearly 150,000 performance data of more than 34,000 polymers and nearly 1.4 million chemical reaction data of 58,516 basic reaction templates.

It is worth mentioning that these data mainly rely on dozens of graduate students and undergraduates in the past three years, especially during the epidemic, to standardize, enter and store them one by one. Based on the database, the team created a machine learning prediction model for more than ten properties of polymers, and built a research and development platform for polymer materials genome, which has multiple functions such as data retrieval, performance prediction and formula optimization.

The reporter saw in the team’s live demonstration that when users use the AI plus polymer software platform to predict the performance of polymer materials, they only need to click "Draw Structure" first, input the drawn strings of epoxy resin and curing agent into the corresponding input boxes, and then click "Start Prediction". After a few seconds, the page will return to the performance prediction data of epoxy resin calculated in the background.

So, how does this software compare with foreign counterparts? For example, Gao Liang, one of the team members and a special researcher at East China University of Science and Technology, has similar software in the United States and Japan. However, in terms of database richness, prediction accuracy and functional diversity, AI plus polymer software platform is superior. "Our goal is to seize the opportunity of digital and artificial intelligence to change the new material industry, develop high-performance polymers and their composites with faster efficiency and lower cost, and realize the original innovation and intelligent manufacturing of polymer materials." Gao Liang said.

The research and development of new materials has entered the era of "intelligent manufacturing" from the era of experience "trial and error"

The development of AI plus polymer software platform can be described as a sword after ten years. It is reported that since 2011, Lin Jiaping’s team has seized the frontier field of material research-material genetic engineering to start related work.

With the cooperation of gene combination screening and AI tools, the team developed a series of advanced composite matrix resins. For example, the curing temperature is less than 300℃, the 5% thermal decomposition temperature is more than 650℃, and the glass transition temperature is more than 600℃. For another example, a new type of high-temperature resistant and high-toughness poly (alkynyl imide) resin is superior to polyimide in processability, heat resistance and interface properties, and its mechanical properties are equivalent to polyimide. Related new resins have been evaluated by many aerospace institutes for the performance of composite materials and components.

"The AI plus polymer software platform is like a polymer virtual laboratory. The virtual design of the platform and the method of high-throughput prediction will greatly improve the research and development efficiency." Lin Jiaping introduced that at present, the platform has been tried in more than ten enterprises such as Shanghai Huayi Group Resin Factory, Shanghai Aerospace Eighth Institute, Jinfei Carbon Fiber Technology and Jinshan Petrochemical Institute, and will be used to the public.

Author: Wu Jinjiao

Editor: Chu Shuting

Editor in charge: Fan Liping

Photo: East China University of Science and Technology

* The exclusive manuscript of Wenhui, please indicate the source.

Heavy weight! Haiqing video brand VI new upgrade

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